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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: JAK1 All Species: 22.73
Human Site: S404 Identified Species: 55.56
UniProt: P23458 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.22
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P23458 NP_002218.2 1154 133277 S404 S S H E E A L S F V S L V D G
Chimpanzee Pan troglodytes Q5IS37 825 92786 Q148 T L S W Q L F Q T L S L R E L
Rhesus Macaque Macaca mulatta XP_001088791 1154 133313 S404 S S H E E A L S F V S L V D G
Dog Lupus familis XP_865130 1147 132539 S398 S S H E E A L S F V S L V D G
Cat Felis silvestris
Mouse Mus musculus P52332 1153 133349 S404 S S R E E A L S F V S L V D G
Rat Rattus norvegicus Q62689 1132 130567 K385 D A H H Y L C K E V A P P A V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q75R65 1129 129828 K383 D A H H Y L C K E V A P P S V
Frog Xenopus laevis NP_001086862 1142 131497 S389 S T P E E A L S F A A L I D G
Zebra Danio Brachydanio rerio O12990 1153 132463 S400 F Y R D A A L S F A A L V D G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24592 1177 135043 S398 Q T E K E M K S F I S Y L G I
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 20.5 99.4 97.4 N.A. 94.6 43.7 N.A. N.A. 43.7 75.8 62.7 N.A. 21.2 N.A. N.A. N.A.
Protein Similarity: 100 35.4 99.6 98.6 N.A. 96.7 62.7 N.A. N.A. 62.7 86.2 76.5 N.A. 40 N.A. N.A. N.A.
P-Site Identity: 100 13.3 100 100 N.A. 93.3 13.3 N.A. N.A. 13.3 66.6 53.3 N.A. 26.6 N.A. N.A. N.A.
P-Site Similarity: 100 40 100 100 N.A. 93.3 26.6 N.A. N.A. 26.6 86.6 66.6 N.A. 53.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 20 0 0 10 60 0 0 0 20 40 0 0 10 0 % A
% Cys: 0 0 0 0 0 0 20 0 0 0 0 0 0 0 0 % C
% Asp: 20 0 0 10 0 0 0 0 0 0 0 0 0 60 0 % D
% Glu: 0 0 10 50 60 0 0 0 20 0 0 0 0 10 0 % E
% Phe: 10 0 0 0 0 0 10 0 70 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 60 % G
% His: 0 0 50 20 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 10 0 0 10 0 10 % I
% Lys: 0 0 0 10 0 0 10 20 0 0 0 0 0 0 0 % K
% Leu: 0 10 0 0 0 30 60 0 0 10 0 70 10 0 10 % L
% Met: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 10 0 0 0 0 0 0 0 0 20 20 0 0 % P
% Gln: 10 0 0 0 10 0 0 10 0 0 0 0 0 0 0 % Q
% Arg: 0 0 20 0 0 0 0 0 0 0 0 0 10 0 0 % R
% Ser: 50 40 10 0 0 0 0 70 0 0 60 0 0 10 0 % S
% Thr: 10 20 0 0 0 0 0 0 10 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 60 0 0 50 0 20 % V
% Trp: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 10 0 0 20 0 0 0 0 0 0 10 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _